FREE SHIPPING ON ORDERS $35+

Research

Explore What's in Noophoric Products

Double-Blind Placebo-Controlled Research Studies

The most accurate type of clinical studies are conducted using placebo control groups in which neither the researcher nor the participant is aware of which particular treatment is being administered. This double-blind study eliminates the bias associated with the placebo effect.


All of the studies referenced with the ingredients below are conducted using this method. We take great consideration of the type of study used to produce results when choosing ingredients for our products. We only reference reliable studies that are conducted on human participants.

Hair+

Saw Palmetto

Saw Palmetto (Serenoa Repens) Extract (Berry)

  • Helps decrease DHT levels

Saw Palmetto is extracted from the berries of the Saw Palmetto fan palm. The main benefit of Saw Palmetto is that it slows the production of the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone or DHT. Excessive DHT in men can lead to pattern baldness. In women, too much DHT can lead to hair growth in unwanted areas. To avoid these issues, Saw Palmetto can work to decrease DHT levels. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/12006122/

Turmeric

Turmeric (Curcuma Longa) (Root) (95% Curcuminoids)

  • Reduces inflammation which can cause hair issues

The active substance in Turmeric is Curcumin. Curcumin has anti-inflammatory properties which can help support a healthy inflammatory response. Inflammation can lead to hair follicle issues, especially in those with medical conditions such as Alopecia. Consuming Curcumin can be a great way to decrease inflammation. 

Biotin

Biotin (as d-Biotin)

  • Improves the health of hair, nails and skin

Biotin is an important vitamin for hair, nails and skin health. Research suggests that Biotin is most beneficial when it is consumed orally from food sources or supplements. Biotin can help build proteins that are necessary to maintain healthy hair and skin, including keratin. A deficiency in Biotin can lead to thinning hair. Several research studies, including one published in Dermatology Research and Practice and another in the Journal of Clinical and Aesthetic Dermatology, have found evidence that suggests Biotin can promote hair growth as well as the reduction of hair loss. The studies found that there was a perceived improvement in hair volume and thickness in the group taking Biotin versus the control group taking the placebo.


Studies:

https://pubmed.ncbi.nlm.nih.gov/25883641/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509882/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582478/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Horsetail

Horsetail (Equisetum Arvense) Extract (Aerial Parts)

  • Helps prevent hair thinning
  • Beneficial for nail health

Horsetail has many benefits, including aiding hair growth and improving brittle nails due to its high concentration of silicic acid and silicates. A double-blind, placebo-controlled study published in the Journal of Clinical and Aesthetic Dermatology found that taking a proprietary supplement with silica derived from Horsetail significantly increased hair growth after 90 and 180 days in subjects with self perceived hair thinning. Horsetail is one of the best sources of silica on earth.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509882/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041289/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938278/

Stinging Nettle

Stinging Nettle (Urtica Dioica) Extract (Root)

  • May help reduce inflammation in the scalp

Stinging Nettle has a number of helpful health benefits. When it comes to hair health, Stinging Nettle can reduce inflammation in the scalp, neutralize free radical damage in the scalp and help block DHT. Although more research on Stinging Nettle is necessary, its ability to act as an anti-inflammatory can be beneficial for individuals with medical conditions with scalp inflammation such as Alopecia.  


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Selenium

Selenium (as Selenium Glycinate Complex)

  • May help encourage hair growth
  • A deficiency can cause hair loss

Selenium is an essential trace element required for the synthesis of over 35 proteins. Selenium can help encourage hair growth by helping the body convert proteins to grow hair. A deficiency in Selenium can cause loss of hair. The antioxidant enzymes in Selenium prevent damage to hair follicles in free radicals. A clinical trial in patients undergoing chemotherapy showed a significant decrease in hair loss when receiving selenium supplementation, compared to the control group. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://www.ncbi.nlm.nih.gov/pubmed/2219873

Folate

Green Tea

Green Tea (Camellia Sinensis) Extract (50% Polyphenols, 15% EGCG)

  • May aid in DHT blocking

The primary catechin in green tea leaves is epigallocatechin-3 gallate or EGCG. EGCG may aid in DHT blocking because it may be able to block 5-alpha-reductase, the enzyme that converts testosterone in DHT. Too much DHT in men can cause pattern baldness and too much DHT in women can cause unwanted hair. In addition, green tea may strengthen hair follicles by increasing nutrient delivery. Research surrounding green tea’s ability to regrow hair is limited, however green tea has been shown to keep existing hair healthy.

L-Lysine

L-Lysine

  • Important amino acid for hair health
  • Shown to help DHT blockers
  • Aids iron and zinc absorption

Lysine is an essential amino acid that must be consumed in diet since it is not produced by the body. According to a study from the National Center for Biotechnology Information, “The role of the essential amino acid, L-Lysine in hair loss also appears to be important. Double-blind data confirmed the findings of an open study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron therapy.” Lysine can help with the absorption of iron and zinc, which is important because iron and zinc deficiencies can also cause hair loss. In addition, Lysine has been shown to make DHT blockers more effective. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://pubmed.ncbi.nlm.nih.gov/12190640/

L-Methionine

L-Methionine 

  • May help to reverse graying hair

Methionine is an essential amino acid that must be consumed through diet. Methionine works to help promote healthy hair and strengthen nails. Recent research also suggests that Methionine may help prevent hair graying and may also reverse it. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

N-Acetyl L-Cysteine

N-Acetyle L-Cysteine

  • Helps restore hair loss
  • Prevents hair dryness

Cysteine is a non-essential amino acid that helps build protein in the body. Cysteine is important when it comes to maintaining healthy hair due to its ability to form disulfide bonds which hold together keratin strands within hair. These strands provide hair with its fibrous properties that are essential to preventing dry hair. Research shows that treating individuals that have hair problems with Cysteine can successfully restore hair growth. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://aminoacidstudies.org/major-study-confirms-that-L-Cysteine-can-reverse-hair-loss/#fnref-2181-3

Iron

Iron (as Ferrous Fumarate)

  • Essential for healthy hair

Iron is an important mineral for hair health. A lack of iron can cause hair loss or damaged hair. Individuals with iron deficiencies often also have thinning hair and even pattern baldness. It is essential to maintain a healthy level of iron to achieve optimal hair growth.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Zinc

Zinc (as Zinc Oxide)

  • Important mineral for hair growth

Zinc is an essential mineral found in many food sources. Deficiencies in Zinc can cause hair loss. The levels of zinc in men experiencing pattern baldness are lower than average. The body does not store excess amounts of zinc, so a constant supply within the diet is necessary. It is important to maintain a healthy level of zinc, especially when it comes to keeping your hair healthy.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Iodine

Iodine (as Potassium Iodine)

  • Helps maintain healthy hair and skin

Iodine is a trace mineral that is essential to many functions in the body. A deficiency in Iodine can lead to issues with hair and skin. Iodine helps with the formation of shiny and healthy skin and hair. The thyroid gland relies on Iodine to make the hormones that are necessary for healthy hair growth. Iodine also prevents dry hair and hair greying problems. Sufficient Iodine levels can make your hair thick and strong from the roots. 

Vitamin Blend: A, C, D3, E, B6, B12, B5

Vitamin A (as Retinul Palmitate)

Vitamin C (Ascorbic Acid)

Vitamin D3 (as Cholecalciferol)

Vitamin E (as Tecopheryl Acetate)

Vitamin B6 (as Pyroxide HCL)

Vitamin B12 (as Methylcobalamin)

Vitamin B5 (as Pantothenic Acid)

  • Necessary for healthy hair growth

Motivation+

KSM-66® Ashwagandha Root

KSM-66® Ashwagandha (Withania Somifera) Extract (Root) (standardized minimum 5% Withanolides)

  • Enhances brain function
  • Reduces feelings of depression and anxiety
  • May improve digestive health

KSM-66® is the highest concentration, highly bioavailable, full spectrum Ashwagandha root extract. 

Ashwagandha root has been clinically shown to have a positive impact on stress, anxiety, memory, cognition, sleep, general health, thyroid function, telomerase activity, aging, weight management, testosterone, muscle strength/recovery, cardio respirator endurance, and sexual function.


Studies:

https://ksm66ashwagandhaa.com/clinical-studies/

Lion's Mane Mushroom

Lion's Mane Mushroom (Hericium Erinaceus) Powder (Fruiting Body)

  • Enhances brain function
  • Reduces feelings of depression and anxiety
  • May improve digestive health

Lion's Mane Mushroom is a popular nootropic that has been claimed to have many health benefits such as boosting cognitive functions and helping reduce anxiety.


According to research published in the International Journal of Medicinal Mushrooms, Lion's Mane effects brain function by enhancing neurite outgrowth which potentially slows or reverses cell degeneration linked to diseases such as Alzheimer’s and Parkinson’s.


Studies have also shown that Lion's Mane can have a significant positive impact on depression and anxiety in patients that consumed the mushroom everyday for 4 weeks.


Studies:

https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en

https://pubmed.ncbi.nlm.nih.gov/26853959/

https://pubmed.ncbi.nlm.nih.gov/24266378/

Alpha GPC

Alpha GPC 50% (L-Alpha Glycerylphosphorylcholine)

  • Enhances brain function
  • Helps improve memory and focus
  • Increases athletic performance

Alpha GPC is known as one of the best nootropics for promoting cognitive health. By delivering choline to the brain, Alpha GPC stimulates neurotransmitters that help brain functions. 


Research indicates that Alpha GPC positively affects memory and may help with symptoms of Alzheimer's and dementia. In addition, Alpha GPC has been shown to help with focus, memory and learning in healthy young adults.


Studies also show that Alpha GPC can help with athletic performance and recovery. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776389/

https://pubmed.ncbi.nlm.nih.gov/12637119/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313098/

Panax Ginseng Root

Panax Ginseng Extract (Root)

  • Reduces levels of anxiety, stress and depression
  • Supports concentration and memory
  • Combats physical fatigue

For centuries, Ginseng has been used in Asia and North America for its many benefits. In addition to aiding the immune system and anti-inflammatory properties, Ginseng has been shown to help with many functions of the brain as wells as improving mood.


A study done by the Brain Performance and Nutrition Research Centre in the United Kingdom found that volunteers that consumed Ginseng had improved mood, calmness and mental arithmetic. Another study by the Department of Neurology at the Clinical Research Institute in South Korea has shown promise for the improvement of mental performance of patients suffering from Alzheimer's disease.


Studies:

https://pubmed.ncbi.nlm.nih.gov/20737519/

https://pubmed.ncbi.nlm.nih.gov/14737017/

https://pubmed.ncbi.nlm.nih.gov/18580589/


Rhodiola Rosea Root

Rhodiola (Rhodiola Rosea) Extract (Root) (std. min. 3% Rosavins; 1% Salidrosides)

  • Adaptogen for reducing stress
  • Helps fight depression and anxiety
  • May help reduce physical fatigue

Rhodiola Rosea is an adaptogen herb, meaning that it helps with the body's natural resistance to stress. In addition, Rhodiola may increase energy and enhance cognitive function. Research suggests that Rhodiola acts on beta-endorphins and opioid neuropeptides to enhance stress tolerance and helping other stress adaption factors. Rhodiola also has a positive effect on athletic performance by increasing energy, strength and stamina. 


Studies:

https://www.ncbi.nlm.nih.gov/pubmed/12725561

https://pubmed.ncbi.nlm.nih.gov/26502953/

https://pubmed.ncbi.nlm.nih.gov/18307390/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541197/

https://www.annualreviews.org/doi/10.1146/annurev.pa.09.040169.002223

https://pubmed.ncbi.nlm.nih.gov/15256690/

https://pubmed.ncbi.nlm.nih.gov/15500079/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790408/

https://pubmed.ncbi.nlm.nih.gov/25837277/


Inositol

Inositol

  • Impacts the nervous system
  • Reduces feelings of depression and anxiety
  • Beneficial for people with mental illnesses

Inositol is a chemical compound that is broken down and used as an energy source in the body. Inositol is essential to the process of building cell membranes and is known to impact the neurotransmitters in the brain, leading to mood-boosting effects. Research has shown that Inositol can have a positive effect on depression, panic disorders, OCD, PMDD and anxiety. One study found that in over 90% of participants given Inositol, it “led to major improvement”. More studies have confirmed these results and have shown a real benefit in using Inositol to treat depression. 


Studies:

https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.470080109

https://pubmed.ncbi.nlm.nih.gov/8780431/

https://pubmed.ncbi.nlm.nih.gov/7726322/

https://pubmed.ncbi.nlm.nih.gov/11386498/

https://pubmed.ncbi.nlm.nih.gov/7793450/

https://www.researchgate.net/publication/5986256_Herbal_and_dietary_supplements_for_treatment_of_anxiety_disorders

L-Taurine

L-Taurine

  • May benefit cognitive performance and memory
  • Promotes positive mood
  • Increases athletic performance

Taurine is an amino acid that is often added to energy drinks for its cognitive performance abilities. Research has found that Taurine plays an important role in creating new brain cells by activating stem cells, specifically brain cells in the hippocampus that relate to memory. Patients with the neurodegenerative disorder, Parkinson’s, have been found to have low levels of Taurine. With age, Taurine levels fall significantly and may affect the body’s ability to heal the brain, heart and kidneys. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/11140366/

https://link.springer.com/article/10.1007/s00726-019-02775-6

https://pubmed.ncbi.nlm.nih.gov/22855206/

https://pubmed.ncbi.nlm.nih.gov/15042451/

L-Carnitine

Acetyl-L-Carnitine

  • Enhances brain function and memory
  • Reverses cognitive decline
  • Increases endurance

Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria where they are used as a fuel source. There are several forms of Carnatine, the type used in Motivation+ is Acetyle-L-Carnatine, which is thought to benefit brain health and memory. This type of Carnatine is also able to pass through the blood-brain barrier. 


In one study aimed at physical endurance, researchers gave Carnatine to professional athletes and found that it prolonged the time it took them to reach exhaustion. In another study, elderly participants were given Carnatine and had a significant decrease in fatigue as well as improved cognitive function. In addition, the participants reduced their total fat mass and increased muscle mass. Other studies have found that Carnatine could help reverse cognitive decline and improve memory in patients with Alzheimer’s disease.


Studies:

https://academic.oup.com/ajcn/article/86/6/1738/4649810

https://pubmed.ncbi.nlm.nih.gov/24263659/

https://pubmed.ncbi.nlm.nih.gov/2178869/

L-Tyrosine

N-Acetyle-L-Tyrosine

  • Reduces feelings of depression and stress
  • May increase energy and help fatigue
  • Beneficial for mental performance in people that are sleep deprived.

Tyrosine is an amino acid that helps the body produce chemicals such as epinephrine, norepinephrine, and dopamine that support your thyroid, energy and mood. The benefits of Tyrosine include reducing depression, increasing cognitive function and decreasing fatigue. Since Tyrosine helps with the production of dopamine, it may also positively influence mood and stress levels. Irritability, fatigue and moodiness tend to increase when levels of dopamine and norepinephrine drop due to stress and depression. One study found that Tyrosine helped improve mental performance in people that were sleep-deprived. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020390/

https://www.sciencedirect.com/science/article/abs/pii/S0022395615002472?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/

https://pubmed.ncbi.nlm.nih.gov/7794222/

L-Theanine

L-Theanine 

  • Reduces feelings of depression, anxiety and stress
  • Improves focus and cognition
  • Helps with sleep

Theanine is an amino acid that can impact nerve impulses in the brain and the release of neurotransmitters. It is often used to reduce anxiety because of its ability to provide a calming effect without causing drowsiness. There have been many studies conducted that prove benefits related to reducing stress, improving sleep and protecting memory and cognition. One study paired Theanine with Caffeine together and found that it improved focus without causing participants to feel overly wired or jittery. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728665/

https://www.ncbi.nlm.nih.gov/pubmed/16930802

https://pubmed.ncbi.nlm.nih.gov/27396868/

https://pubmed.ncbi.nlm.nih.gov/18296328/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870602/

https://pubmed.ncbi.nlm.nih.gov/26869148/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193539/


Natural Caffeine

Natural Caffeine (Coffee Robusta) Extract (Seeds)

  • Enhances energy and focus
  • May improve memory and cognition
  • Helps with athletic performance 

Caffeine is one of the most common supplements used for improving energy, alertness and cognitive function. In addition, caffeine may improve physical performance during exercise. Studies have suggested that caffeine may help slow the mental decline that comes with age. Research has also found that prolonged consumption of caffeine may reduce the risk of developing Alzheimer’s disease and Parkinson’s disease. Research from John Hopkins University suggests that consuming caffeine after studying may help increase long-term memory. 


Studies:

https://www.ncbi.nlm.nih.gov/books/NBK209050/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480845/

5-HTP Seed

5-HTP (5-Hydroxytryptophan) (Griffonia Simplicifolia) (Seed)

  • Helps with the synthesis of serotonin
  • Reduces feelings of depression and anxiety
  • May improve sleep quality

5-HTP comes from the seeds of the African plant Gtiffonia Simplicifolia. The primary function of 5-HTP is to increase the synthesis of serotonin which can potentially have positive effects mood, energy levels, motivation, appetite, sleep and nervous system function. Evidence suggests that 5-HTP can help decrease symptoms of stress, anxiety and depression. Another benefit of 5-HTP is sleep quality. Although it doesn’t cause drowsiness, 5-HTP can help with relaxation. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/8728550/

https://pubmed.ncbi.nlm.nih.gov/19417589/

Huperzine

Huperzine (Huperzia Serrata) Extract (Aerial Parts) (Standardized to 1% Huperzine A)

  • May improve memory

Huperzine is a substance extracted from the Chinese club moss or Huperzia Serrata. This plant has been used in traditional Chinese medicine to reduce inflammation and increase memory. Because of this, Huperzine may be effective as a treatment for Alzheimer’s disease. Huperzine is also used to boost energy and alertness, although research on these benefits are limited. One study published in the Chinese journal Acta Pharmalogica Sinica, found that Huperzine improved memory and learning in young students that complained of decreased memory. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/10678121/

https://pubmed.ncbi.nlm.nih.gov/18425924/

Vitamin Blend: D3, B1, B2, B3, B6, B12, B5

Vitamin D3 (as Cholecalciferol)

Vitamin B1 (as Thiamine HCl)

Vitamin B2 (as Riboflavin-5-Phosphate)

Vitamin B3 (as Niacinamide)

Vitamin B6 (as Pyridoxal-5-Phosphate) (P-5-P)

Vitamin B12 (as Methylcobalamin)

Vitamin B5 (as D-Calcium Pantothenate)

  • Enhances mood
  • Increases energy levels
  • Improves memory
  • Prevents neurological diseases
  • Supports brain function
  • Prevents fatigue
  • Helps with stress and anxiety

Research

Explore What's in Noophoric Products

Double-Blind Placebo-Controlled Research Studies

The most accurate type of clinical studies are conducted using placebo control groups in which neither the researcher nor the participant is aware of which particular treatment is being administered. This double-blind study eliminates the bias associated with the placebo effect.


All of the studies referenced with the ingredients below are conducted using this method. We take great consideration of the type of study used to produce results when choosing ingredients for our products. We only reference reliable studies that are conducted on human participants.

Hair+

Saw Palmetto

Saw Palmetto (Serenoa Repens) Extract (Berry)

  • Helps decrease DHT levels

Saw Palmetto is extracted from the berries of the Saw Palmetto fan palm. The main benefit of Saw Palmetto is that it slows the production of the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone or DHT. Excessive DHT in men can lead to pattern baldness. In women, too much DHT can lead to hair growth in unwanted areas. To avoid these issues, Saw Palmetto can work to decrease DHT levels. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/12006122/

Turmeric

Turmeric (Curcuma Longa) (Root) (95% Curcuminoids)

  • Reduces inflammation which can cause hair issues

The active substance in Turmeric is Curcumin. Curcumin has anti-inflammatory properties which can help support a healthy inflammatory response. Inflammation can lead to hair follicle issues, especially in those with medical conditions such as Alopecia. Consuming Curcumin can be a great way to decrease inflammation. 

Biotin

Biotin (as d-Biotin)

  • Improves the health of hair, nails and skin

Biotin is an important vitamin for hair, nails and skin health. Research suggests that Biotin is most beneficial when it is consumed orally from food sources or supplements. Biotin can help build proteins that are necessary to maintain healthy hair and skin, including keratin. A deficiency in Biotin can lead to thinning hair. Several research studies, including one published in Dermatology Research and Practice and another in the Journal of Clinical and Aesthetic Dermatology, have found evidence that suggests Biotin can promote hair growth as well as the reduction of hair loss. The studies found that there was a perceived improvement in hair volume and thickness in the group taking Biotin versus the control group taking the placebo.


Studies:

https://pubmed.ncbi.nlm.nih.gov/25883641/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509882/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5582478/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Horsetail

Horsetail (Equisetum Arvense) Extract (Aerial Parts)

  • Helps prevent hair thinning
  • Beneficial for nail health

Horsetail has many benefits, including aiding hair growth and improving brittle nails due to its high concentration of silicic acid and silicates. A double-blind, placebo-controlled study published in the Journal of Clinical and Aesthetic Dermatology found that taking a proprietary supplement with silica derived from Horsetail significantly increased hair growth after 90 and 180 days in subjects with self perceived hair thinning. Horsetail is one of the best sources of silica on earth.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509882/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041289/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938278/

Stinging Nettle

Stinging Nettle (Urtica Dioica) Extract (Root)

  • May help reduce inflammation in the scalp

Stinging Nettle has a number of helpful health benefits. When it comes to hair health, Stinging Nettle can reduce inflammation in the scalp, neutralize free radical damage in the scalp and help block DHT. Although more research on Stinging Nettle is necessary, its ability to act as an anti-inflammatory can be beneficial for individuals with medical conditions with scalp inflammation such as Alopecia.  


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Selenium

Selenium (as Selenium Glycinate Complex)

  • May help encourage hair growth
  • A deficiency can cause hair loss

Selenium is an essential trace element required for the synthesis of over 35 proteins. Selenium can help encourage hair growth by helping the body convert proteins to grow hair. A deficiency in Selenium can cause loss of hair. The antioxidant enzymes in Selenium prevent damage to hair follicles in free radicals. A clinical trial in patients undergoing chemotherapy showed a significant decrease in hair loss when receiving selenium supplementation, compared to the control group. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://www.ncbi.nlm.nih.gov/pubmed/2219873

Folate

Green Tea

Green Tea (Camellia Sinensis) Extract (50% Polyphenols, 15% EGCG)

  • May aid in DHT blocking

The primary catechin in green tea leaves is epigallocatechin-3 gallate or EGCG. EGCG may aid in DHT blocking because it may be able to block 5-alpha-reductase, the enzyme that converts testosterone in DHT. Too much DHT in men can cause pattern baldness and too much DHT in women can cause unwanted hair. In addition, green tea may strengthen hair follicles by increasing nutrient delivery. Research surrounding green tea’s ability to regrow hair is limited, however green tea has been shown to keep existing hair healthy.

L-Lysine

L-Lysine

  • Important amino acid for hair health
  • Shown to help DHT blockers
  • Aids iron and zinc absorption

Lysine is an essential amino acid that must be consumed in diet since it is not produced by the body. According to a study from the National Center for Biotechnology Information, “The role of the essential amino acid, L-Lysine in hair loss also appears to be important. Double-blind data confirmed the findings of an open study in women with increased hair shedding, where a significant proportion responded to l-lysine and iron therapy.” Lysine can help with the absorption of iron and zinc, which is important because iron and zinc deficiencies can also cause hair loss. In addition, Lysine has been shown to make DHT blockers more effective. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://pubmed.ncbi.nlm.nih.gov/12190640/

L-Methionine

L-Methionine 

  • May help to reverse graying hair

Methionine is an essential amino acid that must be consumed through diet. Methionine works to help promote healthy hair and strengthen nails. Recent research also suggests that Methionine may help prevent hair graying and may also reverse it. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

N-Acetyl L-Cysteine

N-Acetyle L-Cysteine

  • Helps restore hair loss
  • Prevents hair dryness

Cysteine is a non-essential amino acid that helps build protein in the body. Cysteine is important when it comes to maintaining healthy hair due to its ability to form disulfide bonds which hold together keratin strands within hair. These strands provide hair with its fibrous properties that are essential to preventing dry hair. Research shows that treating individuals that have hair problems with Cysteine can successfully restore hair growth. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

https://aminoacidstudies.org/major-study-confirms-that-L-Cysteine-can-reverse-hair-loss/#fnref-2181-3

Iron

Iron (as Ferrous Fumarate)

  • Essential for healthy hair

Iron is an important mineral for hair health. A lack of iron can cause hair loss or damaged hair. Individuals with iron deficiencies often also have thinning hair and even pattern baldness. It is essential to maintain a healthy level of iron to achieve optimal hair growth.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Zinc

Zinc (as Zinc Oxide)

  • Important mineral for hair growth

Zinc is an essential mineral found in many food sources. Deficiencies in Zinc can cause hair loss. The levels of zinc in men experiencing pattern baldness are lower than average. The body does not store excess amounts of zinc, so a constant supply within the diet is necessary. It is important to maintain a healthy level of zinc, especially when it comes to keeping your hair healthy.


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315033/

Iodine

Iodine (as Potassium Iodine)

  • Helps maintain healthy hair and skin

Iodine is a trace mineral that is essential to many functions in the body. A deficiency in Iodine can lead to issues with hair and skin. Iodine helps with the formation of shiny and healthy skin and hair. The thyroid gland relies on Iodine to make the hormones that are necessary for healthy hair growth. Iodine also prevents dry hair and hair greying problems. Sufficient Iodine levels can make your hair thick and strong from the roots. 

Vitamin Blend: A, C, D3, E, B6, B12, B5

Vitamin A (as Retinul Palmitate)

Vitamin C (Ascorbic Acid)

Vitamin D3 (as Cholecalciferol)

Vitamin E (as Tecopheryl Acetate)

Vitamin B6 (as Pyroxide HCL)

Vitamin B12 (as Methylcobalamin)

Vitamin B5 (as Pantothenic Acid)

  • Necessary for healthy hair growth

Motivation+

KSM-66® Ashwagandha Root

KSM-66® Ashwagandha (Withania Somifera) Extract (Root) (standardized minimum 5% Withanolides)

  • Enhances brain function
  • Reduces feelings of depression and anxiety
  • May improve digestive health

KSM-66® is the highest concentration, highly bioavailable, full spectrum Ashwagandha root extract. 

Ashwagandha root has been clinically shown to have a positive impact on stress, anxiety, memory, cognition, sleep, general health, thyroid function, telomerase activity, aging, weight management, testosterone, muscle strength/recovery, cardio respirator endurance, and sexual function.


Studies:

https://ksm66ashwagandhaa.com/clinical-studies/

Lion's Mane Mushroom

Lion's Mane Mushroom (Hericium Erinaceus) Powder (Fruiting Body)

  • Enhances brain function
  • Reduces feelings of depression and anxiety
  • May improve digestive health

Lion's Mane Mushroom is a popular nootropic that has been claimed to have many health benefits such as boosting cognitive functions and helping reduce anxiety.


According to research published in the International Journal of Medicinal Mushrooms, Lion's Mane effects brain function by enhancing neurite outgrowth which potentially slows or reverses cell degeneration linked to diseases such as Alzheimer’s and Parkinson’s.


Studies have also shown that Lion's Mane can have a significant positive impact on depression and anxiety in patients that consumed the mushroom everyday for 4 weeks.


Studies:

https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en

https://pubmed.ncbi.nlm.nih.gov/26853959/

https://pubmed.ncbi.nlm.nih.gov/24266378/

Alpha GPC

Alpha GPC 50% (L-Alpha Glycerylphosphorylcholine)

  • Enhances brain function
  • Helps improve memory and focus
  • Increases athletic performance

Alpha GPC is known as one of the best nootropics for promoting cognitive health. By delivering choline to the brain, Alpha GPC stimulates neurotransmitters that help brain functions. 


Research indicates that Alpha GPC positively affects memory and may help with symptoms of Alzheimer's and dementia. In addition, Alpha GPC has been shown to help with focus, memory and learning in healthy young adults.


Studies also show that Alpha GPC can help with athletic performance and recovery. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776389/

https://pubmed.ncbi.nlm.nih.gov/12637119/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3313098/

Panax Ginseng Root

Panax Ginseng Extract (Root)

  • Reduces levels of anxiety, stress and depression
  • Supports concentration and memory
  • Combats physical fatigue

For centuries, Ginseng has been used in Asia and North America for its many benefits. In addition to aiding the immune system and anti-inflammatory properties, Ginseng has been shown to help with many functions of the brain as wells as improving mood.


A study done by the Brain Performance and Nutrition Research Centre in the United Kingdom found that volunteers that consumed Ginseng had improved mood, calmness and mental arithmetic. Another study by the Department of Neurology at the Clinical Research Institute in South Korea has shown promise for the improvement of mental performance of patients suffering from Alzheimer's disease.


Studies:

https://pubmed.ncbi.nlm.nih.gov/20737519/

https://pubmed.ncbi.nlm.nih.gov/14737017/

https://pubmed.ncbi.nlm.nih.gov/18580589/


Rhodiola Rosea Root

Rhodiola (Rhodiola Rosea) Extract (Root) (std. min. 3% Rosavins; 1% Salidrosides)

  • Adaptogen for reducing stress
  • Helps fight depression and anxiety
  • May help reduce physical fatigue

Rhodiola Rosea is an adaptogen herb, meaning that it helps with the body's natural resistance to stress. In addition, Rhodiola may increase energy and enhance cognitive function. Research suggests that Rhodiola acts on beta-endorphins and opioid neuropeptides to enhance stress tolerance and helping other stress adaption factors. Rhodiola also has a positive effect on athletic performance by increasing energy, strength and stamina. 


Studies:

https://www.ncbi.nlm.nih.gov/pubmed/12725561

https://pubmed.ncbi.nlm.nih.gov/26502953/

https://pubmed.ncbi.nlm.nih.gov/18307390/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541197/

https://www.annualreviews.org/doi/10.1146/annurev.pa.09.040169.002223

https://pubmed.ncbi.nlm.nih.gov/15256690/

https://pubmed.ncbi.nlm.nih.gov/15500079/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790408/

https://pubmed.ncbi.nlm.nih.gov/25837277/


Inositol

Inositol

  • Impacts the nervous system
  • Reduces feelings of depression and anxiety
  • Beneficial for people with mental illnesses

Inositol is a chemical compound that is broken down and used as an energy source in the body. Inositol is essential to the process of building cell membranes and is known to impact the neurotransmitters in the brain, leading to mood-boosting effects. Research has shown that Inositol can have a positive effect on depression, panic disorders, OCD, PMDD and anxiety. One study found that in over 90% of participants given Inositol, it “led to major improvement”. More studies have confirmed these results and have shown a real benefit in using Inositol to treat depression. 


Studies:

https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.470080109

https://pubmed.ncbi.nlm.nih.gov/8780431/

https://pubmed.ncbi.nlm.nih.gov/7726322/

https://pubmed.ncbi.nlm.nih.gov/11386498/

https://pubmed.ncbi.nlm.nih.gov/7793450/

https://www.researchgate.net/publication/5986256_Herbal_and_dietary_supplements_for_treatment_of_anxiety_disorders

L-Taurine

L-Taurine

  • May benefit cognitive performance and memory
  • Promotes positive mood
  • Increases athletic performance

Taurine is an amino acid that is often added to energy drinks for its cognitive performance abilities. Research has found that Taurine plays an important role in creating new brain cells by activating stem cells, specifically brain cells in the hippocampus that relate to memory. Patients with the neurodegenerative disorder, Parkinson’s, have been found to have low levels of Taurine. With age, Taurine levels fall significantly and may affect the body’s ability to heal the brain, heart and kidneys. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/11140366/

https://link.springer.com/article/10.1007/s00726-019-02775-6

https://pubmed.ncbi.nlm.nih.gov/22855206/

https://pubmed.ncbi.nlm.nih.gov/15042451/

L-Carnitine

Acetyl-L-Carnitine

  • Enhances brain function and memory
  • Reverses cognitive decline
  • Increases endurance

Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria where they are used as a fuel source. There are several forms of Carnatine, the type used in Motivation+ is Acetyle-L-Carnatine, which is thought to benefit brain health and memory. This type of Carnatine is also able to pass through the blood-brain barrier. 


In one study aimed at physical endurance, researchers gave Carnatine to professional athletes and found that it prolonged the time it took them to reach exhaustion. In another study, elderly participants were given Carnatine and had a significant decrease in fatigue as well as improved cognitive function. In addition, the participants reduced their total fat mass and increased muscle mass. Other studies have found that Carnatine could help reverse cognitive decline and improve memory in patients with Alzheimer’s disease.


Studies:

https://academic.oup.com/ajcn/article/86/6/1738/4649810

https://pubmed.ncbi.nlm.nih.gov/24263659/

https://pubmed.ncbi.nlm.nih.gov/2178869/

L-Tyrosine

N-Acetyle-L-Tyrosine

  • Reduces feelings of depression and stress
  • May increase energy and help fatigue
  • Beneficial for mental performance in people that are sleep deprived.

Tyrosine is an amino acid that helps the body produce chemicals such as epinephrine, norepinephrine, and dopamine that support your thyroid, energy and mood. The benefits of Tyrosine include reducing depression, increasing cognitive function and decreasing fatigue. Since Tyrosine helps with the production of dopamine, it may also positively influence mood and stress levels. Irritability, fatigue and moodiness tend to increase when levels of dopamine and norepinephrine drop due to stress and depression. One study found that Tyrosine helped improve mental performance in people that were sleep-deprived. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020390/

https://www.sciencedirect.com/science/article/abs/pii/S0022395615002472?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/

https://pubmed.ncbi.nlm.nih.gov/7794222/

L-Theanine

L-Theanine 

  • Reduces feelings of depression, anxiety and stress
  • Improves focus and cognition
  • Helps with sleep

Theanine is an amino acid that can impact nerve impulses in the brain and the release of neurotransmitters. It is often used to reduce anxiety because of its ability to provide a calming effect without causing drowsiness. There have been many studies conducted that prove benefits related to reducing stress, improving sleep and protecting memory and cognition. One study paired Theanine with Caffeine together and found that it improved focus without causing participants to feel overly wired or jittery. 


Studies:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728665/

https://www.ncbi.nlm.nih.gov/pubmed/16930802

https://pubmed.ncbi.nlm.nih.gov/27396868/

https://pubmed.ncbi.nlm.nih.gov/18296328/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870602/

https://pubmed.ncbi.nlm.nih.gov/26869148/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193539/


Natural Caffeine

Natural Caffeine (Coffee Robusta) Extract (Seeds)

  • Enhances energy and focus
  • May improve memory and cognition
  • Helps with athletic performance 

Caffeine is one of the most common supplements used for improving energy, alertness and cognitive function. In addition, caffeine may improve physical performance during exercise. Studies have suggested that caffeine may help slow the mental decline that comes with age. Research has also found that prolonged consumption of caffeine may reduce the risk of developing Alzheimer’s disease and Parkinson’s disease. Research from John Hopkins University suggests that consuming caffeine after studying may help increase long-term memory. 


Studies:

https://www.ncbi.nlm.nih.gov/books/NBK209050/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480845/

5-HTP Seed

5-HTP (5-Hydroxytryptophan) (Griffonia Simplicifolia) (Seed)

  • Helps with the synthesis of serotonin
  • Reduces feelings of depression and anxiety
  • May improve sleep quality

5-HTP comes from the seeds of the African plant Gtiffonia Simplicifolia. The primary function of 5-HTP is to increase the synthesis of serotonin which can potentially have positive effects mood, energy levels, motivation, appetite, sleep and nervous system function. Evidence suggests that 5-HTP can help decrease symptoms of stress, anxiety and depression. Another benefit of 5-HTP is sleep quality. Although it doesn’t cause drowsiness, 5-HTP can help with relaxation. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/8728550/

https://pubmed.ncbi.nlm.nih.gov/19417589/

Huperzine

Huperzine (Huperzia Serrata) Extract (Aerial Parts) (Standardized to 1% Huperzine A)

  • May improve memory

Huperzine is a substance extracted from the Chinese club moss or Huperzia Serrata. This plant has been used in traditional Chinese medicine to reduce inflammation and increase memory. Because of this, Huperzine may be effective as a treatment for Alzheimer’s disease. Huperzine is also used to boost energy and alertness, although research on these benefits are limited. One study published in the Chinese journal Acta Pharmalogica Sinica, found that Huperzine improved memory and learning in young students that complained of decreased memory. 


Studies:

https://pubmed.ncbi.nlm.nih.gov/10678121/

https://pubmed.ncbi.nlm.nih.gov/18425924/

Vitamin Blend: D3, B1, B2, B3, B6, B12, B5

Vitamin D3 (as Cholecalciferol)

Vitamin B1 (as Thiamine HCl)

Vitamin B2 (as Riboflavin-5-Phosphate)

Vitamin B3 (as Niacinamide)

Vitamin B6 (as Pyridoxal-5-Phosphate) (P-5-P)

Vitamin B12 (as Methylcobalamin)

Vitamin B5 (as D-Calcium Pantothenate)

  • Enhances mood
  • Increases energy levels
  • Improves memory
  • Prevents neurological diseases
  • Supports brain function
  • Prevents fatigue
  • Helps with stress and anxiety